LDH and Cholesterol Metabolism in Canine HSA

by Effie Machiavello | Aug 16, 2026 | Hemangio Journal

A new study has found a link between lactate metabolism and cholesterol regulation in canine hemangiosarcoma, and shown that combining a statin with dipyridamole delayed tumour growth in mouse models. The study looked at lactate dehydrogenase (LDH) in canine HSA....

RNA Expression Reveals Distinct Subtypes of Canine Splenic HSA

by Effie Machiavello | Aug 8, 2026 | Hemangio Journal

A new study from Brazil has used gene expression profiling to identify three distinct molecular subtypes of canine splenic hemangiosarcoma, each with different therapeutic implications. The study analyzed tumor samples from 27 dogs with splenic HSA using a 48-gene...

Lipid Radiosensitizer Suppresses HSA Growth Without Direct Cell Kill

by Effie Machiavello | Jul 17, 2026 | Hemangio Journal

SQAP (sulfoquinovosylacylpropanediol), a lipid-based radiosensitizer commercialized as Lavurchin, showed no direct cytotoxicity against canine hemangiosarcoma cells in vitro but significantly suppressed tumor growth in three patient-derived xenograft models. This...

Doxorubicin as Rescue Therapy for Acute Hemorrhage in Presumed HSA

by Effie Machiavello | Jul 10, 2026 | Hemangio Journal

This retrospective study of 30 dogs explores whether doxorubicin can serve as a rescue therapy for dogs presenting with acute hemorrhage from suspected hemangiosarcoma when surgery isn’t feasible, and the results suggest it can. All 30 dogs presented with active...

Liquid Biopsy Screening Could Double Cancer Detection in Dogs

by Effie Machiavello | Jul 6, 2026 | Hemangio Journal

The Cancer Lifetime Assessment Screening Study in Canines (CLASSiC) offered the first interim results from a prospective, multi-center study evaluating next-generation sequencing (NGS)-based liquid biopsy as a longitudinal cancer screening tool in dogs. The study...